Comparison of chromosomal location of basal cell smoking-dysregulated genes to known COPD risk loci.

<p><b>A.</b> Chromosomal distribution of SNPs identified by GWAS (p<10⁻⁵) as risk loci for COPD and related phenotypes. <b>B.</b> Chromosomal location of the 676 significant smoking-dysregulated basal cell (BC) genes as compared to distribution expected by random chance. Red dots represent the number of BC smoking-dysregulated genes localized to each chromosome. Box and whisker plots represent 10⁴ permutations of 676 randomly chosen genes. The red dots above chromosomes 16, 19 and 22 represent the number of BC smoking-dysregulated genes in each location, along with the % of total dysregulated genes on each chromosome. <b>C.</b> Enrichment of 676 BC smoking-dysregulated genes on known COPD risk loci. Red dots represent number of BC smoking-dysregulated genes at each known COPD risk loci; the loci are identified by chromosome number and chromosome subband. Box and whisker plots represent the distribution of 676 randomly chosen genes permutated 10⁴ times for each GWAS chromosome subband location. The only statistically significant locus was 19q13.2 (p<10⁻⁴).