Actin polymerization is decreased in human PBMCs stimulated with CXCL12.

<p>Primary human PBMCs pre-incubated with DMSO, WHI-P131 or PTX were stimulated with 300 ng/mL of CXCL12 at different time points. F-actin was detected as described above. Representative histograms (n = 4) (<i>top</i>) and graphs (<i>bottom</i>) of the F-actin increment are shown. The graph represents the average values of 4 independent experiments ± SEM. Significance was calculated using a paired Student's t test (one tailed). Asterisks indicate statistical significant values, *<i>p</i><0.05, **<i>p</i><0.01.