The ubiquitous thioredoxin fold proteins catalyze oxidation, reduction, or disulfide exchange reactions depending on their redox properties. They also play vital roles in protein folding, redox control, and disease. Here, we have shown that a single residue strongly modifies both the redox properties of thioredoxin fold proteins and their ability to interact with substrates. This residue is adjacent in three-dimensional space to the characteristic CXXC active site motif of thioredoxin fold proteins but distant in sequence. This residue is just N-terminal to the conservative cis-proline. It is isoleucine 75 in the case of thioredoxin. Our findings support the conclusion that a very small percentage of the amino acid residues of thioredoxin-r...
Thioredoxins (Trx) are a class of small multifunctional 12-kDa proteins that are characterized by th...
ABSTRACT: High-molecular mass thioredoxin reductases (TRs) are pyridine nucleotide disulfide oxidore...
vi, 118 leaves : ill. (some col.) ; 30 cm.PolyU Library Call No.: [THS] LG51 .H577M ABCT 2002 YuThio...
AbstractThe thioredoxin fold is a characteristic protein structural motif that has been found in fiv...
AbstractThiol–disulfide oxidoreductase systems of bacterial cytoplasm and eukaryotic cytosol favor r...
AbstractBackground: Human thioredoxin reduces the disulfide bonds of numerous proteins in vitro, and...
SummaryThioredoxin is ubiquitous and regulates various target proteins through disulfide bond reduct...
AbstractBackground: The redox proteins that incorporate a thioredoxin fold have diverse properties a...
AbstractThe recent high-resolution solution structures of human and Escherichia coli thioredoxin in ...
The variety of cellular functions performed by proteins of the thioredoxin superfamily is made possi...
Background: Disulfide exchange reactions are catalyzed by thiol/disulfide oxidoreductases. These enz...
The group of proteins that contain a thioredoxin (Trx) fold is huge and diverse. Assessment of the v...
The group of proteins that contain a thioredoxin (Trx) fold is huge and diverse. Assessment of the v...
20 páginas. -- The final version is available at http://www.elsevier.comThioredoxins (Trxs) are low-...
AbstractThe human redox protein thioredoxin is an autocrine growth factor for some cancer cells. Red...
Thioredoxins (Trx) are a class of small multifunctional 12-kDa proteins that are characterized by th...
ABSTRACT: High-molecular mass thioredoxin reductases (TRs) are pyridine nucleotide disulfide oxidore...
vi, 118 leaves : ill. (some col.) ; 30 cm.PolyU Library Call No.: [THS] LG51 .H577M ABCT 2002 YuThio...
AbstractThe thioredoxin fold is a characteristic protein structural motif that has been found in fiv...
AbstractThiol–disulfide oxidoreductase systems of bacterial cytoplasm and eukaryotic cytosol favor r...
AbstractBackground: Human thioredoxin reduces the disulfide bonds of numerous proteins in vitro, and...
SummaryThioredoxin is ubiquitous and regulates various target proteins through disulfide bond reduct...
AbstractBackground: The redox proteins that incorporate a thioredoxin fold have diverse properties a...
AbstractThe recent high-resolution solution structures of human and Escherichia coli thioredoxin in ...
The variety of cellular functions performed by proteins of the thioredoxin superfamily is made possi...
Background: Disulfide exchange reactions are catalyzed by thiol/disulfide oxidoreductases. These enz...
The group of proteins that contain a thioredoxin (Trx) fold is huge and diverse. Assessment of the v...
The group of proteins that contain a thioredoxin (Trx) fold is huge and diverse. Assessment of the v...
20 páginas. -- The final version is available at http://www.elsevier.comThioredoxins (Trxs) are low-...
AbstractThe human redox protein thioredoxin is an autocrine growth factor for some cancer cells. Red...
Thioredoxins (Trx) are a class of small multifunctional 12-kDa proteins that are characterized by th...
ABSTRACT: High-molecular mass thioredoxin reductases (TRs) are pyridine nucleotide disulfide oxidore...
vi, 118 leaves : ill. (some col.) ; 30 cm.PolyU Library Call No.: [THS] LG51 .H577M ABCT 2002 YuThio...