PTH enhanced angiogenesis at the peri-infarct region 14 days after stroke.

<p>Fourteen days after stroke, endothelial cells and cell proliferation at the peri-infarct region was inspected using immunohistochemical methods. <b>A</b> and <b>B</b>. Representative Glut-1 (green) staining of vascular endothelial cells in the brain section from stroke/saline and stroke/PTH mice. <b>C</b>. The area of Glut-1 fluorescent reactivity in stroke/saline and stroke/PTH groups. <b>D</b> to <b>I</b>. Fluorescent labeling of Glut-1+ (green) and BrdU+ (red) cells. F and I are 3-D images showing co-localized labeling of Glut-1 and BrdU, indicative of angiogenesis. <b>J</b>. Quantified data of fluorescent reactivity of Glut-1/BrdU double positive cells; PTH treatment significantly promoted angiogenesis. N = 6; ** <i>P</i><0.01 vs. stroke control.