Downregulation of miR-196a inhibited proliferation of pancreatic cancer cell line PANC-1.

<p>(A) Transfection of anti-miR-196a and anti-miR-NC in PANC-1. (B) Comparision of transfection rate between anti-miR-196a and anti-miR-NC in PANC-1. The transfection rate of anti-miR-196a was (88.76±2.25)%, while the transfection rate of anti-miR-NC was (91.09±1.77)% (<i>P</i>>0.05). (C) Expression of miR-196a by qRT-PCR. (D) Growth curve among anti-miR-196a, anti-miR-NC and parental PANC-1 cells. Cell proliferation was significantly reduced in anti-miR-196a group compared with that of anti-miR-NC group at 72 h (*, <i>P<0.05</i>). <i>LM</i>: light microscope.