Lithium (Li)-induced nuclear translocation of β-catenin in BrdU(+) cells generated following neuronal loss.

<p>Animals were given either lithium carbonate (100 mg/kg, i.p.) or PBS with BrdU on day 2 post-treatment with TMT, subsequently given once a day either lithium carbonate or PBS on days 3 and 5, and then decapitated on day 30 post-treatment for preparation of sagittal hippocampal sections, which were then stained with antibodies against β-catenin and BrdU (Schedule 2). (<b>a</b>) Fluorescence micrographs show localization of BrdU (<i>red</i>) and β-catenin (<i>green</i>) in the dentate gyrus of the 2 groups (impaired/PBS, impaired/Li₂CO₃). Scale bar = 100 µm (<b>b</b>) Graph denoting the number of BrdU(+) cells with nuclear β-catenin in the GCL+SGZ of each group. Values are expressed as the mean ± S.E., calculated from 5 animals. **<i>P</i><0.01, significant difference between the values obtained for PBS and Li groups.