Effect of alcohol and acetaldehyde on system β and System A activity in BeWo cells.

<p>Na⁺-dependent ³H taurine uptake (system β activity) and Na⁺-dependent ¹⁴C-MeAIB uptake (system A activity) of BeWo cells over time. (a) system β activity and (b) system A activity, over 10, 20 and 30 minutes (Mean 23282±4809, SE = 2151, N = 6). The least squares linear regression shows that uptake was linearly related to time in all cases (p≤0.05). (c) System β activity of BeWo cells at 30 minutes. Ethanol treatment at 10 mM and 40 mM significantly decreased transporter activity (p<0.05; N = 6). (d) Acetaldehyde exposure did not change system β activity after 30 minutes (N = 6; p>0.05). (e) System A activity was not affected by ethanol or (f) acetaldehyde (N = 6; p>0.05). Statistical analysis with Wilcoxon signed-rank. <b>*</b>p<0.05 vs control.