<p>Comparative genome hybridization of 100 large cells (red line) and small cells (blue line) each yielded identical chromosomal profiles. Both populations show gains at chromosomes 2q, 5q, 7, 17q and losses at 2q, 6p, 9p, 10p, 10q, 12p, 17p and 22. Small gains at chromosomes 2q as well as a small loss at chromosome 17q were detected in the large cell phenotype. This indicates that both morphologically different cell types evolved from a common clonal origin. Bars on the left of the moving average indicate losses of DNA. Bars on the right of the moving average indicate gains of DNA. Both profiles are in line with previously published data <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0087663#pone.0087663-Rinner1" tar...
<p>A. GFP copy number in the evolved strains: GFP DNA copy number was measured using real-time PCR. ...
Comparative genomic hybridization (CGH) allows the detection of DNA sequence copy number changes on ...
<p>Panel <b>(A)</b> illustrates an increase in the number of <i>CUP1</i> repeats on the W303-1A alle...
Genetic instability results, in a large majority of solid tumors, in deep chromosomal rearrangements...
A large database of copy number profiles from cancer genomes can facilitate the identification of re...
Array comparative genomic hybridization, with a genome-wide resolution of approximately 1 Mb, has be...
Array comparative genomic hybridization, with a genome-wide resolution of approximately 1 Mb, has be...
In this study, 23 ovarian cancer cell lines were screened using array-comparative genomic hybridizat...
<p><b>Panel A:</b> Graphical whole-genome views of copy number aberrations (CNAs) identified in both...
<p>A) Array CGH profile of Kasumi-3, B) MUTZ-3 and C) UCSD-AML1 indicating the 0.39 Mb SRO on 7q35 a...
<p><b>Panel A:</b> Graphical whole-genome views of copy number aberrations (CNAs) identified in both...
Genetic instability results, in a large majority of solid tumors, in deep chromosomal rearrangements...
<p>Along the top is shown the gene map of a “zoomed-in” 10 Kb portion of Chromosome 14 (from coordin...
<p>(<b>A</b>) The log base 2 ratio of the aCGH hybridization intensity for chrV L for <i>hph</i>− is...
<p>(<b>A</b>) The log base 2 ratio of the aCGH hybridization intensity for chrV L of <i>hph</i>+ iso...
<p>A. GFP copy number in the evolved strains: GFP DNA copy number was measured using real-time PCR. ...
Comparative genomic hybridization (CGH) allows the detection of DNA sequence copy number changes on ...
<p>Panel <b>(A)</b> illustrates an increase in the number of <i>CUP1</i> repeats on the W303-1A alle...
Genetic instability results, in a large majority of solid tumors, in deep chromosomal rearrangements...
A large database of copy number profiles from cancer genomes can facilitate the identification of re...
Array comparative genomic hybridization, with a genome-wide resolution of approximately 1 Mb, has be...
Array comparative genomic hybridization, with a genome-wide resolution of approximately 1 Mb, has be...
In this study, 23 ovarian cancer cell lines were screened using array-comparative genomic hybridizat...
<p><b>Panel A:</b> Graphical whole-genome views of copy number aberrations (CNAs) identified in both...
<p>A) Array CGH profile of Kasumi-3, B) MUTZ-3 and C) UCSD-AML1 indicating the 0.39 Mb SRO on 7q35 a...
<p><b>Panel A:</b> Graphical whole-genome views of copy number aberrations (CNAs) identified in both...
Genetic instability results, in a large majority of solid tumors, in deep chromosomal rearrangements...
<p>Along the top is shown the gene map of a “zoomed-in” 10 Kb portion of Chromosome 14 (from coordin...
<p>(<b>A</b>) The log base 2 ratio of the aCGH hybridization intensity for chrV L for <i>hph</i>− is...
<p>(<b>A</b>) The log base 2 ratio of the aCGH hybridization intensity for chrV L of <i>hph</i>+ iso...
<p>A. GFP copy number in the evolved strains: GFP DNA copy number was measured using real-time PCR. ...
Comparative genomic hybridization (CGH) allows the detection of DNA sequence copy number changes on ...
<p>Panel <b>(A)</b> illustrates an increase in the number of <i>CUP1</i> repeats on the W303-1A alle...