<p>Schematic illustration of the three experimental strategies used for determining whether exposure to mitomycin C (MMC) induces trafficking of Pgp to the plasma membrane in hCMEC/D3-Pgp-EGFP cells.</p
The demarcation membrane system (DMS) is an extensive plasma membrane invagination system of the meg...
The demarcation membrane system (DMS) is an extensive plasma membrane invagination system of the meg...
<p>(A) Upper panel: Immunodetection of EdU incorporation (green) and mitotic cells (pH3-positive, re...
<p>A representative experiment is shown. hCMEC/D3-MDR1-EGFP (doxycycline-on) cells were pretreated w...
<p>(A) hCMEC/D3-MDR1-EGFP (doxycycline-on) cells were treated with MMC (1 µM) for 2 or 4 h and analy...
<p>MMC significantly increased the functionality of Pgp-EGFP fusion protein. “A”: hCMEC/D3-Pgp-EGFP ...
P-glycoprotein (Pgp; ABCB1/MDR1) is a major efflux transporter at the blood-brain barrier (BBB), res...
P-glycoprotein (Pgp; ABCB1/MDR1) is a major efflux transporter at the blood-brain barrier (BBB), res...
Previous studies have demonstrated that mitomycin C (MMC) and other DNA cross-linking agents can sup...
<p>Schematic illustration of the mechanism associated with the Cd-induced elevation of c-Myc in HepG...
<p>The bar graphs show the effects of different inhibitors and temperature on cellular uptake of (a)...
<p>The figure shows data in which eFluxx-ID Gold uptake was measured directly after 2 h of MMC (1 µM...
<p>Doxycycline-induced hCMEC/D3-MDR1-EGFP cells were treated with MMC (1 µM) for 2 or 4 h and analyz...
<p>Images of SKOV-3<sub>TR</sub> cells incubated with various fluorescent substrates of Pgp1 in the ...
<p>(A) Schematic drawing of mSmo mutations in the four arginine motifs. (B) <i>Gli</i>-luc reporter ...
The demarcation membrane system (DMS) is an extensive plasma membrane invagination system of the meg...
The demarcation membrane system (DMS) is an extensive plasma membrane invagination system of the meg...
<p>(A) Upper panel: Immunodetection of EdU incorporation (green) and mitotic cells (pH3-positive, re...
<p>A representative experiment is shown. hCMEC/D3-MDR1-EGFP (doxycycline-on) cells were pretreated w...
<p>(A) hCMEC/D3-MDR1-EGFP (doxycycline-on) cells were treated with MMC (1 µM) for 2 or 4 h and analy...
<p>MMC significantly increased the functionality of Pgp-EGFP fusion protein. “A”: hCMEC/D3-Pgp-EGFP ...
P-glycoprotein (Pgp; ABCB1/MDR1) is a major efflux transporter at the blood-brain barrier (BBB), res...
P-glycoprotein (Pgp; ABCB1/MDR1) is a major efflux transporter at the blood-brain barrier (BBB), res...
Previous studies have demonstrated that mitomycin C (MMC) and other DNA cross-linking agents can sup...
<p>Schematic illustration of the mechanism associated with the Cd-induced elevation of c-Myc in HepG...
<p>The bar graphs show the effects of different inhibitors and temperature on cellular uptake of (a)...
<p>The figure shows data in which eFluxx-ID Gold uptake was measured directly after 2 h of MMC (1 µM...
<p>Doxycycline-induced hCMEC/D3-MDR1-EGFP cells were treated with MMC (1 µM) for 2 or 4 h and analyz...
<p>Images of SKOV-3<sub>TR</sub> cells incubated with various fluorescent substrates of Pgp1 in the ...
<p>(A) Schematic drawing of mSmo mutations in the four arginine motifs. (B) <i>Gli</i>-luc reporter ...
The demarcation membrane system (DMS) is an extensive plasma membrane invagination system of the meg...
The demarcation membrane system (DMS) is an extensive plasma membrane invagination system of the meg...
<p>(A) Upper panel: Immunodetection of EdU incorporation (green) and mitotic cells (pH3-positive, re...