Heterologous prime (WNV-DermaVir nanoparticles) - boost (WNV-E protein) protect mice against a lethal WNV challenge.

<p>Two groups of 10 BALB/c mice were vaccinated IM or topically (top) with WNV-DermaVir nanoparticles and boosted with WNV-E protein combined with Matrix-M1 four weeks later. Nine control mice were vaccinated with WNV-DermaVir nanoparticles containing an egfp control plasmid. Two weeks after the boost, the mice were challenged i.p. with a lethal dose of WNV. Abbreviations: bE: boost E-protein.