Murine model of acute tuberculosis infection.

<p>Log₁₀ reduction provided by compound <b>9a</b> in lungs (black bars) and spleen (grey bars) after 9 days of daily oral administration of 300 mg/kg was determined by calculating the difference between bacillary loads in organs from the untreated group and <b>9a</b> dissolved in (<b>1</b>) 0.5% methylcellulose in DI-H₂O (<b>2</b>) 30% captisol in DI-H₂O (<b>3</b>) 10% vitamin E TPGS in DI-H₂O (<b>4</b>) 0.5% Tween 80 in DI-H₂O (<b>5</b>) 20% cyclodextrin in DI-H₂O or (<b>6</b>) cold PEG (50∶35∶15 H₂O:PEG300:PG). Error bars indicate SEM within treatment groups of 5–7 mice per group.