Control theoretic model analysis.

<p>The overall model is analyzed by decomposing it into upstream and downstream levels. A: The functions used to describe the activation of Zds1, PP2A and Pkc1. B: The solutions of the downstream Zds1 - PP2A system (for fixed ) correspond to the intersections of the two graphs; see <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1003443#pcbi.1003443.e134" target="_blank">equation (2)</a>. C: Bifurcation graph for the downstream Zds1 - PP2A system. D: the solutions of the upstream Rho1/Pkc1 system (for fixed ) correspond to the intersections of these graphs; see <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1003443#pcbi.1003443.e163" target="_blank">equation (3)</a>. E: Bifurcation graph for the upstream Rho1 - Pkc1 system. F: Both bifurcation graphs superimposed - the steady states of the full model correspond to the intersection of these two graphs.