<div><p>Overexpression of the inducible heat shock protein 70, Hsp72, has broadly cytoprotective effects and improves outcome following stroke. A full understanding of how Hsp72 protects cells against injury is elusive, though several distinct mechanisms are implicated. One mechanism is its anti-inflammatory effects. We study the effects of Hsp72 overexpression on activation of the transcription factor NF-κB in microglia combining experimentation and mathematical modeling, using TNFα to stimulate a microglial cell line stably overexpressing Hsp72. We find that Hsp72 overexpression reduces the amount of NF-κB DNA binding activity, activity of the upstream kinase IKK, and amount of IκBα inhibitor phosphorylated following TNFα application. Sim...
Heat shock (HS) treatment has been previously shown to suppress the IkappaB/nuclear factor-kappaB (N...
Heat shock proteins (HSPs) are chaperones that catalyze the refolding of denatured proteins. In addi...
Causes of lower induction of Hsp70 in neurons during heat shock are still a matter of debate. To fur...
Overexpression of the inducible heat shock protein 70, Hsp72, has broadly cytoprotective effects and...
Overexpression of the inducible heat shock protein 70, Hsp72, has broadly cytoprotective effects and...
The 70-kDa heat shock protein (Hsp70) is involved in protecting the brain from a variety of insults ...
<p>Hsp72 regulation at the upstream level inhibiting IKK is an essential component in microglia, alt...
Inflammation is an important event in ischemic injury. These immune responses begin with the express...
Inflammation is an important event in ischemic injury. These immune responses begin with the express...
We and others have previously shown that heat-shock proteins (HSPs) are involved in protecting the b...
The major heat shock protein, Hsp70, can protect against cell death by directly interfering with mit...
Heat shock proteins (HSPs) are chaperones that catalyze the refolding of denatured proteins. In addi...
Heat shock proteins (HSPs) are induced in response to many injuries including stroke, neurodegenerat...
Heat shock cognate protein 70 (HSC70), a molecular chaperone, is constitutively expressed by mammali...
Heat shock proteins (HSPs) are induced in response to many injuries including stroke, neurodegenerat...
Heat shock (HS) treatment has been previously shown to suppress the IkappaB/nuclear factor-kappaB (N...
Heat shock proteins (HSPs) are chaperones that catalyze the refolding of denatured proteins. In addi...
Causes of lower induction of Hsp70 in neurons during heat shock are still a matter of debate. To fur...
Overexpression of the inducible heat shock protein 70, Hsp72, has broadly cytoprotective effects and...
Overexpression of the inducible heat shock protein 70, Hsp72, has broadly cytoprotective effects and...
The 70-kDa heat shock protein (Hsp70) is involved in protecting the brain from a variety of insults ...
<p>Hsp72 regulation at the upstream level inhibiting IKK is an essential component in microglia, alt...
Inflammation is an important event in ischemic injury. These immune responses begin with the express...
Inflammation is an important event in ischemic injury. These immune responses begin with the express...
We and others have previously shown that heat-shock proteins (HSPs) are involved in protecting the b...
The major heat shock protein, Hsp70, can protect against cell death by directly interfering with mit...
Heat shock proteins (HSPs) are chaperones that catalyze the refolding of denatured proteins. In addi...
Heat shock proteins (HSPs) are induced in response to many injuries including stroke, neurodegenerat...
Heat shock cognate protein 70 (HSC70), a molecular chaperone, is constitutively expressed by mammali...
Heat shock proteins (HSPs) are induced in response to many injuries including stroke, neurodegenerat...
Heat shock (HS) treatment has been previously shown to suppress the IkappaB/nuclear factor-kappaB (N...
Heat shock proteins (HSPs) are chaperones that catalyze the refolding of denatured proteins. In addi...
Causes of lower induction of Hsp70 in neurons during heat shock are still a matter of debate. To fur...