Number of γH2AX foci in AR42J cells at 24 and 48 h after incubation with 225Ac-DOTATOC (left) and 177Lu-DOTATOC (right).

NVP-AUY922 in combination with radiation increases micronuclei formation and nuclear volume.

Shane Zaidi (170919)
Martin McLaughlin (170920)
Shreerang A. Bhide (170923)
Suzanne A. Eccles (170928)
Paul Workman (54973)
Christopher M. Nutting (170936)
Robert A. Huddart (170939)
Kevin J. Harrington (170942)

April 2012

The cell lines indicated were treated with vehicle only or NVP-AUY922 for 24 h before mock irradi...

Dotplot representation of RAD51 foci distribution.

Andrea Enguita-Marruedo (6251009)
Marta Martín-Ruiz (6251012)
Eva García (2529628)
Ana Gil-Fernández (6251015)
María Teresa Parra (17269)
Alberto Viera (17271)
Julio S. Rufas (78151)
Jesús Page (17272)

February 2019

(A) Analysis of RAD51 distribution by recovery time. Four substages were considered (MP: mid pachyte...

Cell cycle distribution of CCD-34Lu cells at 6 and 24h from irradiation with 0.5 and 5 Gy of γ-rays.

Leonardo Bee (432795)
Sonia Fabris (207768)
Roberto Cherubini (432796)
Maddalena Mognato (184807)
Lucia Celotti (184804)

July 2013

(A) X axis, DNA content; Y axis, number of cells.*P<0.05; **P<0.01; ***P<0.0...

Comparison of cell viability and the number of γH2AX foci in AR42J cells at 48 h after incubation with 225Ac-DOTATOC and 177Lu-DOTATOC.

Franziska Graf (582705)
Jörg Fahrer (454565)
Stephan Maus (582706)
Alfred Morgenstern (372625)
Frank Bruchertseifer (372624)
Senthil Venkatachalam (582707)
Christian Fottner (582708)
Matthias M. Weber (582709)
Johannes Huelsenbeck (201895)
Mathias Schreckenberger (582710)
Bernd Kaina (22761)
Matthias Miederer (372618)

February 2014

Comparison of cell viability and the number of γH2AX foci in AR42J cells at 48 h after incubation...

Combination of rucaparib with radiation increases χH2AX and 53BP1 foci leading to persistent DNA damage.

Payel Chatterjee (397793)
Gaurav S. Choudhary (397794)
Arishya Sharma (397795)
Kamini Singh (32638)
Warren D. Heston (397796)
Jay Ciezki (397797)
Eric A. Klein (138229)
Alexandru Almasan (3962)

April 2013

χH2AX (A) and 53BP1 (B) foci were determined by immunofluoresecence microsco...

Immunofluorescence staining of DNA double strand breaks (γH2AX) in AR42J tumors after treatment with 47 kBq 225Ac-DOTATOC, 30 MBq of 177Lu-DOTATOC, 1 µg DOTATOC (unlabelled), or PBS.

Franziska Graf (582705)
Jörg Fahrer (454565)
Stephan Maus (582706)
Alfred Morgenstern (372625)
Frank Bruchertseifer (372624)
Senthil Venkatachalam (582707)
Christian Fottner (582708)
Matthias M. Weber (582709)
Johannes Huelsenbeck (201895)
Mathias Schreckenberger (582710)
Bernd Kaina (22761)
Matthias Miederer (372618)

February 2014

(A) Representative images, (B) and quantification of γH2AX- positive cells. Scale bar (whi...

NVP-AUY922 delays radiation induced Rad51 foci formation and DNA damage repair.

Shane Zaidi (170919)
Martin McLaughlin (170920)
Shreerang A. Bhide (170923)
Suzanne A. Eccles (170928)
Paul Workman (54973)
Christopher M. Nutting (170936)
Robert A. Huddart (170939)
Kevin J. Harrington (170942)

April 2012

HeLa and HN3 cells were plated in glass bottom dishes and after attachment exposed to NVP-AUY922 ...

γH2AX foci after exposure to IR (2 Gy).

Ana B. Herrero (705733)
Jesús San Miguel (687105)
Norma C. Gutierrez (5662486)

March 2015

(A) Representative images of γH2AX foci in untreated cells, and in cells irradiated with 2 Gy 1h,...

Confocal microscopy after γΗ2ΑX immunostaining, showing red foci in the nuclei of control (6a1,6a3) and irradiated cells (6a2,6a4), with (6a3,6a4) and without (6a1,6a2) pre-incubation with SMER28 (Fig. 6a).

Dimitra Kalamida (500598)
Ilias V. Karagounis (596219)
Alexandra Giatromanolaki (6784)
Michael I. Koukourakis (596220)

July 2014

Computerized calculation of γH2AX foci in the nuclei of cells. Statistical significance refers to...

Quantification of the number of foci present after treatment with compounds 1–3 and 2–5.

Àlex L. González (2580466)
Piotr Konieczny (2554498)
Beatriz Llamusi (542708)
Estefanía Delgado-Pinar (4068424)
José I. Borrell (2495122)
Jordi Teixidó (2580469)
Enrique García-España (700056)
Manuel Pérez-Alonso (4068418)
Roger Estrada-Tejedor (2580463)
Rubén Artero (4068421)

June 2017

(A) Quantification of foci per cell from the analysis of a minimum of 1000 DM1 fibroblast nuclei ...

Detection of γ-H2AX in Daudi cells following AA3 treatment.

Shanqiao Wei (4446301)
Madusha L. W. Perera (4446298)
Ramin Sakhtemani (4446304)
Ashok S. Bhagwat (111506)

September 2017

(A) Daudi cells were stained with anti-γ-H2AX antibodies and visualized using immunofluorescence....

γ-H2AX foci formation in GSCs.

Jing Hao (291247)
Andrew Godley (5641898)
Jocelyn D. Shoemake (5641901)
Zheyi Han (137514)
Anthony Magnelli (5641904)
Jennifer S. Yu (5641907)

August 2018

(A) Representative immunofluorescence images of 387 GSCs harvested at 30 min, 24 hrs and 48 hours af...

Quantification of residual γ-H2AX 24 h after radiation with different doses.

Yuan-yuan Qu (446755)
Song-liu Hu (446756)
Xiang-ying Xu (446757)
Rui-zhi Wang (446758)
Hong-yang Yu (446759)
Jian-yu Xu (446760)
Lin Chen (54305)
Guang-lu Dong (446761)

August 2013

A549 and MCF-7 cells were pretreated with or without 700 nM nimotuzumab for 24 h, and then were r...

Accumulation of γH2AX and appearance of 53PB1-positive regions in spontaneously occurring or induced DNA lesions.

Eva Bártová (338281)
Gabriela Šustáčková (338282)
Lenka Stixová (338283)
Stanislav Kozubek (338284)
Soňa Legartová (338286)
Veronika Foltánková (338288)

February 2013

A, Appearance of 53BP1-positive foci (red) in heterochromatin (accumulated blue) and euchr...

The formation of γH2AX foci in cells with shortened telomeres.

Orit Uziel (367255)
Einat Beery (367256)
Vladimir Dronichev (367257)
Katty Samocha (367258)
Sergei Gryaznov (367259)
Lola Weiss (365487)
Shimon Slavin (285279)
Michal Kushnir (367260)
Yardena Nordenberg (367261)
Claudette Rabinowitz (367262)
Baruch Rinkevich (53919)
Tania Zehavi (367263)
Meir Lahav (367264)

February 2013

SK-N-MC cells were exposed to cisplatinum or doxorubicin for 1 hour and then resuspended in drug ...

NVP-AUY922 in combination with radiation increases micronuclei formation and nuclear volume.

Shane Zaidi (170919)
Martin McLaughlin (170920)
Shreerang A. Bhide (170923)
Suzanne A. Eccles (170928)
Paul Workman (54973)
Christopher M. Nutting (170936)
Robert A. Huddart (170939)
Kevin J. Harrington (170942)

April 2012

The cell lines indicated were treated with vehicle only or NVP-AUY922 for 24 h before mock irradi...

Dotplot representation of RAD51 foci distribution.

Andrea Enguita-Marruedo (6251009)
Marta Martín-Ruiz (6251012)
Eva García (2529628)
Ana Gil-Fernández (6251015)
María Teresa Parra (17269)
Alberto Viera (17271)
Julio S. Rufas (78151)
Jesús Page (17272)

February 2019

(A) Analysis of RAD51 distribution by recovery time. Four substages were considered (MP: mid pachyte...

Cell cycle distribution of CCD-34Lu cells at 6 and 24h from irradiation with 0.5 and 5 Gy of γ-rays.

Leonardo Bee (432795)
Sonia Fabris (207768)
Roberto Cherubini (432796)
Maddalena Mognato (184807)
Lucia Celotti (184804)

July 2013

(A) X axis, DNA content; Y axis, number of cells.*P<0.05; **P<0.01; ***P<0.0...

Comparison of cell viability and the number of γH2AX foci in AR42J cells at 48 h after incubation with 225Ac-DOTATOC and 177Lu-DOTATOC.

Franziska Graf (582705)
Jörg Fahrer (454565)
Stephan Maus (582706)
Alfred Morgenstern (372625)
Frank Bruchertseifer (372624)
Senthil Venkatachalam (582707)
Christian Fottner (582708)
Matthias M. Weber (582709)
Johannes Huelsenbeck (201895)
Mathias Schreckenberger (582710)
Bernd Kaina (22761)
Matthias Miederer (372618)

February 2014

Comparison of cell viability and the number of γH2AX foci in AR42J cells at 48 h after incubation...

Combination of rucaparib with radiation increases χH2AX and 53BP1 foci leading to persistent DNA damage.

Payel Chatterjee (397793)
Gaurav S. Choudhary (397794)
Arishya Sharma (397795)
Kamini Singh (32638)
Warren D. Heston (397796)
Jay Ciezki (397797)
Eric A. Klein (138229)
Alexandru Almasan (3962)

April 2013

χH2AX (A) and 53BP1 (B) foci were determined by immunofluoresecence microsco...

Immunofluorescence staining of DNA double strand breaks (γH2AX) in AR42J tumors after treatment with 47 kBq 225Ac-DOTATOC, 30 MBq of 177Lu-DOTATOC, 1 µg DOTATOC (unlabelled), or PBS.

Franziska Graf (582705)
Jörg Fahrer (454565)
Stephan Maus (582706)
Alfred Morgenstern (372625)
Frank Bruchertseifer (372624)
Senthil Venkatachalam (582707)
Christian Fottner (582708)
Matthias M. Weber (582709)
Johannes Huelsenbeck (201895)
Mathias Schreckenberger (582710)
Bernd Kaina (22761)
Matthias Miederer (372618)

February 2014

(A) Representative images, (B) and quantification of γH2AX- positive cells. Scale bar (whi...

NVP-AUY922 delays radiation induced Rad51 foci formation and DNA damage repair.

Shane Zaidi (170919)
Martin McLaughlin (170920)
Shreerang A. Bhide (170923)
Suzanne A. Eccles (170928)
Paul Workman (54973)
Christopher M. Nutting (170936)
Robert A. Huddart (170939)
Kevin J. Harrington (170942)

April 2012

HeLa and HN3 cells were plated in glass bottom dishes and after attachment exposed to NVP-AUY922 ...

γH2AX foci after exposure to IR (2 Gy).

Ana B. Herrero (705733)
Jesús San Miguel (687105)
Norma C. Gutierrez (5662486)

March 2015

(A) Representative images of γH2AX foci in untreated cells, and in cells irradiated with 2 Gy 1h,...

Confocal microscopy after γΗ2ΑX immunostaining, showing red foci in the nuclei of control (6a1,6a3) and irradiated cells (6a2,6a4), with (6a3,6a4) and without (6a1,6a2) pre-incubation with SMER28 (Fig. 6a).

Dimitra Kalamida (500598)
Ilias V. Karagounis (596219)
Alexandra Giatromanolaki (6784)
Michael I. Koukourakis (596220)

July 2014

Computerized calculation of γH2AX foci in the nuclei of cells. Statistical significance refers to...

Quantification of the number of foci present after treatment with compounds 1–3 and 2–5.

Àlex L. González (2580466)
Piotr Konieczny (2554498)
Beatriz Llamusi (542708)
Estefanía Delgado-Pinar (4068424)
José I. Borrell (2495122)
Jordi Teixidó (2580469)
Enrique García-España (700056)
Manuel Pérez-Alonso (4068418)
Roger Estrada-Tejedor (2580463)
Rubén Artero (4068421)

June 2017

(A) Quantification of foci per cell from the analysis of a minimum of 1000 DM1 fibroblast nuclei ...

Detection of γ-H2AX in Daudi cells following AA3 treatment.

Shanqiao Wei (4446301)
Madusha L. W. Perera (4446298)
Ramin Sakhtemani (4446304)
Ashok S. Bhagwat (111506)

September 2017

(A) Daudi cells were stained with anti-γ-H2AX antibodies and visualized using immunofluorescence....

γ-H2AX foci formation in GSCs.

Jing Hao (291247)
Andrew Godley (5641898)
Jocelyn D. Shoemake (5641901)
Zheyi Han (137514)
Anthony Magnelli (5641904)
Jennifer S. Yu (5641907)

August 2018

(A) Representative immunofluorescence images of 387 GSCs harvested at 30 min, 24 hrs and 48 hours af...

Quantification of residual γ-H2AX 24 h after radiation with different doses.

Yuan-yuan Qu (446755)
Song-liu Hu (446756)
Xiang-ying Xu (446757)
Rui-zhi Wang (446758)
Hong-yang Yu (446759)
Jian-yu Xu (446760)
Lin Chen (54305)
Guang-lu Dong (446761)

August 2013

A549 and MCF-7 cells were pretreated with or without 700 nM nimotuzumab for 24 h, and then were r...

Accumulation of γH2AX and appearance of 53PB1-positive regions in spontaneously occurring or induced DNA lesions.

Eva Bártová (338281)
Gabriela Šustáčková (338282)
Lenka Stixová (338283)
Stanislav Kozubek (338284)
Soňa Legartová (338286)
Veronika Foltánková (338288)

February 2013

A, Appearance of 53BP1-positive foci (red) in heterochromatin (accumulated blue) and euchr...

The formation of γH2AX foci in cells with shortened telomeres.

Orit Uziel (367255)
Einat Beery (367256)
Vladimir Dronichev (367257)
Katty Samocha (367258)
Sergei Gryaznov (367259)
Lola Weiss (365487)
Shimon Slavin (285279)
Michal Kushnir (367260)
Yardena Nordenberg (367261)
Claudette Rabinowitz (367262)
Baruch Rinkevich (53919)
Tania Zehavi (367263)
Meir Lahav (367264)

February 2013

SK-N-MC cells were exposed to cisplatinum or doxorubicin for 1 hour and then resuspended in drug ...

NVP-AUY922 in combination with radiation increases micronuclei formation and nuclear volume.

Shane Zaidi (170919)
Martin McLaughlin (170920)
Shreerang A. Bhide (170923)
Suzanne A. Eccles (170928)
Paul Workman (54973)
Christopher M. Nutting (170936)
Robert A. Huddart (170939)
Kevin J. Harrington (170942)

April 2012

The cell lines indicated were treated with vehicle only or NVP-AUY922 for 24 h before mock irradi...

Dotplot representation of RAD51 foci distribution.

Andrea Enguita-Marruedo (6251009)
Marta Martín-Ruiz (6251012)
Eva García (2529628)
Ana Gil-Fernández (6251015)
María Teresa Parra (17269)
Alberto Viera (17271)
Julio S. Rufas (78151)
Jesús Page (17272)

February 2019

(A) Analysis of RAD51 distribution by recovery time. Four substages were considered (MP: mid pachyte...

Cell cycle distribution of CCD-34Lu cells at 6 and 24h from irradiation with 0.5 and 5 Gy of γ-rays.

Leonardo Bee (432795)
Sonia Fabris (207768)
Roberto Cherubini (432796)
Maddalena Mognato (184807)
Lucia Celotti (184804)

July 2013

(A) X axis, DNA content; Y axis, number of cells.*P<0.05; **P<0.01; ***P<0.0...

Number of γH2AX foci in AR42J cells at 24 and 48 h after incubation with <sup>225</sup>Ac-DOTATOC (left) and <sup>177</sup>Lu-DOTATOC (right).

Abstract

Extracted data

Number of γH2AX foci in AR42J cells at 24 and 48 h after incubation with <sup>225</sup>Ac-DOTATOC (left) and <sup>177</sup>Lu-DOTATOC (right).

Abstract

Extracted data

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