G551D/F508del subjects.

<p>Summary of results for CF subjects with G551D mutations. Six adult G551D CF subjects were tested. Table is arranged by subject and condition, each row shows the results for a single test or means/sums when multiple tests were performed. Subjects had been taking ivacaftor for at least 3 weeks prior to (+) ivacaftor testing. Columns labeled ‘gland numbers’ show the number of glands that secreted to an intradermal injection of MCh, then to the β-adrenergic cocktail at the same site (C-sweat), and the ratio of the two expressed as a percentage. Columns labeled ‘gland volumes/rates’ show the average final M-sweat or C-sweat volumes per gland expressed as nanoliters for a 15 min period (M-sweat) or 30 min period (C-sweat) followed by average rates (per min, per gland). The 4 columns labeled ‘ratios’ show: 1) the mean C-sweat rate as a percent of the mean M-sweat rate; 2) the C/M ratios as a percentage of the average C/M ratio of 0.2651 obtained for 6 control subjects <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0088564#pone.0088564-Wine1" target="_blank">[10]</a>; 3) that value for the 12 glands having the highest M-sweat rates; and 4) the value for the 12 highest glands after correcting for sweat volume loss.