Diclofenac administration following λ-carrageenan injection attenuates PIP-induced paw edema and hyperalgesia.

<p>Animals received subcutaneous injections of saline (Sal) or λ-carrageenan (Carr) into the plantar surface of the right hind paw (injected). 15 min after paw treatment animals received saline (Sal, 1 mL/kg, i.p.) or diclofenac (Diclo, 30 mg/kg, i.p.) <b>A</b>) Administration of diclofenac resulted in a significant decrease in paw edema in λ-carrageenan treated animals 3 h post paw treatment. Edema of the untreated left hind paw (contralateral) was comparable in all treatment groups. <b>B</b>) Administration of diclofenac attenuated λ-carrageenan -induced hyperalgesia 3 h post paw treatment. Data are reported as mean ± SEM from at least nine animals per treatment group. Asterisks represent data points that are statically different as indicated (*p<0.05).