Demographic and clinical characteristics of schizophrenia subjects and unaffected siblings.

<p>Abbreviations: CI, confidence interval; SANS, Schedule for the Assessment of Negative Symptoms; SAPS, Schedule for the Assessment of Positive Symptoms; SD, standard deviation; WRAT-3, Wide Range Achievement Test, 3rd edition.</p>a<p>Unaffected siblings represent 279 families, of which 17 (6%) were multiplex.</p>b<p>Between-group <i>P</i> values are based on generalized linear mixed-effects models for categorical variables and linear mixed-effects models for continuous variables; <i>P</i> values were not computed for race, multiplex status, parental education, or age at onset of symptoms.</p>c<p>For continuous variables, differences between groups (probands – unaffected siblings) and 95% CIs for differences are based on linear mixed-effects models; for categorical variables, odds ratios and 95% CIs for odds ratios are based on generalized linear mixed-effects models. CIs are shown only for variables where the <i>P</i> value for the between-group test is <0.05.</p>d<p>4 missing values for schizophrenia subjects; 2 missing values for unaffected siblings.</p>e<p>Multiplex families were those for which at least one parent or sibling of the proband had a history of schizophrenia or schizoaffective disorder.</p>f<p>2 missing values for schizophrenia subjects; 2 missing values for unaffected siblings.</p>g<p>6 missing values for schizophrenia subjects; 3 missing values for unaffected siblings.</p>h<p>10 missing values for schizophrenia subjects; 12 missing values for unaffected siblings.</p>i<p>5 missing values for schizophrenia subjects.</p>j<p>7 missing values for schizophrenia subjects; 73 missing values for unaffected siblings.</p>k<p>7 missing values for schizophrenia subjects; 74 missing values for unaffected siblings.