Histological analysis of 16 and 28 week old <i>GHL⁺</i> and <i>GHL⁺/Chop^−/−</i> mice.

<p>(A) Representative sections of retinas from 16 week old C57BL/6, <i>Chop^−/−</i>, <i>GHL⁺</i> and <i>GHL⁺/Chop^−/−</i> mice. <i>GHL⁺</i> and <i>GHL⁺/Chop^−/−</i> retinas had shortened OS (arrowheads). (B, <i>right panel</i>) Mean number of photoreceptor nuclei per column counted in the ONL at 16 weeks. The variance in the number of photoreceptor nuclei per column counted in different zones of the retina in (B, <i>left panel</i>) in 16 week. (C) Representative sections of retinas from 28 week old <i>GHL⁺</i> and <i>GHL⁺/Chop^−/−</i> mice. (D) The variance in the number of photoreceptor nuclei per column counted in different zones of the retina in 28 week old <i>GHL⁺</i> and <i>GHL⁺/Chop^−/−</i> mice. Superior zone: 630 µm from the CMZ, central zone: 630 µm from optic nerve, and inferior zone: midpoint of inferior hemisphere. Error bars: ± SD OPL: outer plexiform layer, ONL: outer nuclear layer, OS: outer segment. Scale bar 50 µm.