Trajectories for a hypothetical male of 60 years at time 0 of body mass index (A), waist circumference (B), systolic blood pressure (C), and diastolic blood pressure (D) from 18 years before time of diagnosis/last examination.

<p>Trajectories for blood pressure represent a person not on anti-hypertensive treatment. Solid lines indicate estimated trajectories for each group and dashed lines are 95% confidence limits. Black bars at the bottom indicate the relative data distribution over the follow-up period. Trajectories of BMI for a hypothetical female of 50 years of age at time of diagnosis are shown in <a href="http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.1001602#pmed.1001602.s001" target="_blank">Figure S1</a>. Light blue, stable overweight; dark blue, progressive weight gain; red, persistently obese; grey, diabetes-free population.