Percentage change in inflammatory markers throughout PEs in CF.

<p>Inflammatory markers were measured in blood plasma from CF patients throughout PE. The percentage change was calculated at each time point and compared to a 0% change which indicates no change from baseline (represented by dotted horizontal line). A) CRP levels were significantly increased from baseline values on Day 1 of PE (p = 0.001) and Day 42 (p = 0.039). B) IL-6 levels were significantly higher on Day 1 of PE (p = 0.006). C) IL-8 concentrations were significantly higher on Day 1 (p = 0.047) and significantly lower than baseline values after treatment on Day 21 (p = 0.022). D) IL-10 levels rose significantly on Days 7 (p = 0.021) and Day 14 (p = 0.046). E) MIP-1β increased from baseline on Days 1 (p = 0.020) and Day 42 (p = 0.023). F) VEGF levels were significantly higher on Day 1 of PE (p = 0.043). Solid horizontal lines are set at the mean * indicates a significant difference from 0% change from baseline. Day 1, n = 13; Day 7, n = 12, Day 14, n = 11; Day 21, n = 9; Day 42, n = 8. Full data set is found in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0088567#pone.0088567.s003" target="_blank">Table S2</a>.