Percentage change of clinical and QOL parameters throughout PEs in CF.

<p>A) FEV1% (<i>blue, circles</i>) and FVC% (<i>red, squares</i>) were significantly reduced from baseline values at Day 1 of PE (FEV1% p = 0.001; FVC% p = 0.010). Both parameters subsequently improved with treatment however, FVC% significantly declined at Day 42 (p = 0.028). The Clinical subscore of the Matouk Disease score (<i>green, triangles</i>) was significantly decreased from baseline values on Day 1 (p = 0.000) and Day 7 (p = 0.045). See <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0088567#pone.0088567.s002" target="_blank">Table S1</a> for the results of other Matouk Disease subscores. B) QOL items also decreased with PE onset, Day 1, such as Respiratory (<i>blue, circles</i>, p = 0.002), Physical (<i>red, squares</i>, p = 0.025) and Health Perceptions domains (<i>green, triangles</i>, p = 0.000). The Physical and Health Perceptions domains remained decreased at Day 7 (p = 0.025 and p = 0.001, respectively). Other QOL domains which decreased at Day 1 include: Vitality, Health Perceptions, Social and Role (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0088567#pone.0088567.s002" target="_blank">Table S1</a>). The dotted horizontal line indicates a 0% change or no change from baseline values. * indicates a significant difference from baseline. Day 1, n = 13; Day 7, n = 12, Day 14, n = 11; Day 21, n = 9; Day 42, n = 8. Full table of results can be found in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0088567#pone.0088567.s002" target="_blank">Table S1</a>.