Center dependent effects of iNO therapy on post-transplant liver function.

<p>Liver function post-transplantation was assessed by following post-surgery time-dependent changes in serum AST, serum ALT, PT time, alkaline phosphatase and bilirubin as indicated. Panels A,B, C shows respectively data for Center A, Center B and the two centers combined. Data represented by symbols (□ = placebo, • = iNO) are presented as percent change relative to first measurement post-surgery and are mean ± SEM (n = 20, except Center A placebo where n = 19; n = 39–40 for combined). Fitted lines (solid line = placebo, dotted line = iNO) show means after adjustment for MELD, cold ischemic time, weight, BMI (>25), warm ischemia time (WIT) and donor age. P-values indicate significance of iNO vs. placebo for adjusted data. Absolute values for LFT parameters measured immediately (<1 h) post-surgery for were: AST 722.8±114 U/L (placebo) and 636.1±136.9 U/L (iNO) at Center A; 1432.1±222.5 U/L (placebo) and 1429.1±134.3 U/L (iNO) at Center B; ALT 479.5±67.1 U/L (placebo) and 423.7±77.8 U/L (iNO) at Center A; 904.3±155.4 U/L (placebo) and 987.7±109.2 U/L (iNO) at Center B; PT time 31.9±2.4 s (placebo) and 31.7±2 s (iNO) at Center A; 22.6±0.8 s (placebo) and 24.6±0.8 s (iNO) at Center B; Alk Phos 77.7±14.3 U/L (placebo) and 70.1±8.9 U/L (iNO) at Center A; 57.2±4.4 U/L (placebo) and 68.4±13 U/L (iNO) at Center B; Bili-total 3.6±0.4 (placebo) and 3.66±0.33 (iNO) at Center A; 3.2±0.5 (placebo) and 4.2±0.5 U/L (iNO) at Center B. Data are normalized to ALT and AST levels measured immediately (<1 h) post-surgery and were 601.8±145.4 U/L (placebo) and 689.3±149.5 U/L (iNO) for ALT and 922.1±228.7 U/L (placebo) and 940.9±211.3 U/L (iNO) for AST.