EDL contractile function was assessed in isolated whole EDL muscle, at optimal length, at 30°Celsius.

<p>A: Twitch force: Twitch force at optimal length was not significantly different between groups. B: Total force: tetanic force at optimal length was not significantly different between groups. C: Specific force: force normalized to the muscle’s cross-sectional area revealed C57BL/10 mice have significantly higher forces than untreated <i>mdx</i> mice, TS, and TSP groups, *P<0.05. C: C57BL/10, n = 8; U: untreated <i>mdx</i> mice, n = 6, P: Prednisolone treated <i>mdx</i> mice, n = 9, LS: Lisinopril-Spironolactone treated <i>mdx</i> mice, n = 10; LSP, Lisinopril-Spironolactone-Prednisolone treated <i>mdx</i> mice n = 6; TS: Losartan-Spironolactone treated <i>mdx</i> mice, n = 11; TSP: Losartan-Spironolactone-Prednisolone treated <i>mdx</i> mice, n = 8.