Impact of siRNA on incubation and survival time.
- Sylvain Lehmann (372399)
- Aroa Relano-Gines (5657977)
- Sarah Resina (262615)
- Elsa Brillaud (523509)
- Danielle Casanova (440682)
- Charles Vincent (221163)
- Claire Hamela (440680)
- Sophie Poupeau (523510)
- Mathieu Laffont (523511)
- Audrey Gabelle (440679)
- Constance Delaby (147365)
- Maxime Belondrade (440681)
- Jacques-Damien Arnaud (523512)
- Maria-Teresa Alvarez (523513)
- Jean-Claude Maurel (523514)
- Patrick Maurel (462470)
- Carole Crozet (51171)
Publication date
February 2014
DOIAbstract
<p>Panel A. The incubation time in scrapie infected mice based on the presence of at least three clinical signs (among: waddling gait, flattened back, rough coat, sticky eye discharge, weight loss, very jumpy, hunched, incontinence) was plotted as medians and interquartile ranges in the three groups: Aonys/PrP<sup>C</sup> siRNA (siPrP 600 µg/kg), Aonys vehicle only and Aonys/scrambled-siRNA. The survival times of the three groups of infected mice were plotted as medians and interquartile ranges (Panel B.) and Kaplan-Meier survival curves (Panel C.). No statistical difference was observed between each group neither for the incubation period nor the survival time.</p
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