Proposed 3D model for MC1 bound to DNA.

<p>(A) Superimposition of two positions for double-strand DNA (orange and red spheres) after docking on the MC1 static molecular shape (green-blue, cartoon or spheres) by interactive driving of the flexible ligand through electrostatic potential of the protein, in accordance with the experimental data. (B) Ten final models for the DNA-MC1 complex (silver cartoon and colored cartoon respectively) proposed after all-atom reconstruction. Average DNA axis curvature measured by the Curves program on these models is 109±6°. (C) Superimposition of 2 of the 8 models of DNA-MC1 complex resulting from HADDOCK. The DNA angle curvature seems to be correlated to the position of the flexible protein LP5 loop: 122° for model 1 (blue) and 81° for model 8 (pink).