Estrogen modulated changes in proliferation kinetics.

<p>(A) Doubling time in each group, the mean doubling time is reduced by 12 hours in the E2 group compared to the Veh and E2 + ICI groups, indicating that adding ICI returns the doubling time to control levels. (B) Percent change in the mean cell mass over the measurement period for each group. A significant decrease in the cell mass is observed in both the E2 and E2+ICI groups compared to the control. (C) Measured doubling time vs. change in mean cell mass for each cluster that was measured, these two parameters can be used to separate the three groups completely and can serve as a growth signature.