Number of GDDIs [6], DOMINE domain-pairs [18] and 3did domain-pairs [19] found in the top 100 domain-pairs.

<p>Of the four rankings (all made under scenario A conditions), <b>oA</b> contains the most number of GDDIs, DOMINE domain-pairs and 3did domain-pairs in the top 100 domain-pairs (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0088943#pone.0088943.s002" target="_blank">File S2</a>). The 26 GDDIs for <b>oA</b> intersect with, but is not the same set as, the 26 3did domain-pairs for <b>oA</b>. Amongst <b>oA</b>’s top 100 domain-pairs is domain-pair (TPR, WD40) which is not a GDDI and whose interaction is neither recorded in DOMINE nor predicted by 3did. However, a possible 3D structure for the obesity-related protein adipose (adp) involves interaction between TPR and WD40 domains <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0088943#pone.0088943-Hder1" target="_blank">[20]</a>.