Genome-wide single QTL scans for atherosclerotic plaque size at the root.

<p>(A) LOD curves for the root lesion with sex as an additive covariate (black line) and as an interactive covariate (red line). X-axis represents positions on chromosome (cM) and y-axis represents the LOD score. The horizontal dashed lines represent the thresholds for significant QTL (p = 0.05) and suggestive QTL (p = 0.63) in the sex-interactive model. (B) Differences in LOD curves of the sex-additive model and the sex-interactive model (LODi). (C) LOD curves for root lesion in males (blue line) and females (red line). The horizontal dashed lines represent the thresholds for significant QTL (p = 0.05) and suggestive QTL (p = 0.63) in males (blue) and females (red). The arrow indicates the second QTL on Chr 1 in females.