Chelator and anti-cancer drug interactions in MCF-7 cells as a function of activity.

<p>The computer simulations of the combination index (<i>CI</i>)-cellular proliferation (fraction affected - F<i>a</i>) dependency were obtained using CalcuSyn 2.0 software following a 72 h incubation of MCF-7 cells with combinations of the studied compounds at concentrations corresponding to their IC₅₀ values and IC₅₀ fractions and multiples (1/8, 1/4, 1/2, 1, 2, and 4). Results are means of <i>n</i>≥4 experiments.