Wild-type p53 cells, but not p53 null or mutant p53 cells, are growth inhibited by TGFβ.

<p>(<b>a</b>) Western blot analysis of stable cell lines to knockdown of p53 by shRNA plasmid or expression of mutant p53 R273H. C = control, T = TGFβ treated. (<b>b</b>) SB-431542 (5 μM) was used to inhibit TGFβ signaling. For each panel, data represents mean ± SEM p≤0.05 increase over untreated for groups labeled with a, or between treated groups labeled with b. (<b>c</b>) Cell survival. Percentage of TGFβ-treated cell survival compared to untreated. Data represent mean ± SEM, *p≤0.05.