Energy expenditure (A), physical activity (B) and respiratory exchange ratio (RER) (C) were measured by indirect calorimetry in C57BL/6J mice after 3 wks of feeding respective diets.

<p>Gray bars represent night periods in A. Significant differences between groups are denoted by differing superscripts. Insulin sensitivity was assessed by measuring blood glucose levels before and during an insulin tolerance test after 3 wks on respective diets. Data are presented before, and at 15, 30, 60 and 120 mins after injection of insulin (<b>D</b>) and as the area under the curve (AUC) for each treatment group (<b>E</b>). (<b>F</b>) Fasting blood glucose levels are also reported. All values are shown as the mean ± SEM.