Mitogen-activated protein kinase signaling in human thyroid cancer cells treated with local anesthetics.

<p>8505C (<b>A</b>) and K1 (<b>B</b>) cells were treated with lidocaine (12 mM) and bupivacaine (4 mM) for various periods of time, and activities of ERK, p38, and JNK were examined by Western blot analysis using phospho-specific antibodies. The total protein levels of ERK, p38, and JNK were also measured.