Number of BrdU-positive cells in the DG in different experimental groups (see table under the abscissa;+done, - not done).

<p>(A) Overview and (B) magnified detail (red square) of a 40 µm thick coronal section through the DG 42 days after the first BrdU-injection. BrdU-positive cells are labelled dark brown. (C) The NC group (n = 7) and the CXray group (n = 7) were not significantly different, and the AIA group (n = 7) did not differ from the IC group (n = 10). Both the AIA and the IC group had significantly increased numbers of BrdU-positive cells compared to the NC and CXray groups. The column on the right shows another group of 3 rats which were only immunized but not tested for pain-related or locomotor behavior (IC-wt). This group did not significantly differ from the IC group. Data are presented as means ± SEM. **p<0.01; ***p<0.001.