Normal locomotor activity in CD47 KO mice.

<p>In the open field test, (A) CD47 KO mice stayed significantly longer in the center of area of the apparatus than wild-type mice during the earlier part of the experimental period, but not over the entire experimental period. No significant differences were detected in total distance traveled (B), vertical activity (C), or stereotypic counts (D). CD47 KO mice, n = 19; wild-type mice, n = 20. CD47 KO mice and wild-type mice were also subjected to the light/dark transition test (E–F). Time spent in the light box (E) and number of transitions (F) did not significantly differ between genotypes. CD47 KO mice, n = 20; wild-type mice, n = 20. The elevated plus maze test was also performed (G–H). There were no significant differences between the genotypes in the number of entries to the open arms (G) or time spent on the open arms (H). CD47 KO mice, n = 20; wild-type mice, n = 20.