Effect of PC and aPC on leukocyte adhesion in <i>RAGE^−/−</i> mice compared to WT control mice.

<p>Comparison of intravital microscopic data of leukocyte adhesion (number of adherent cells per mm²) during trauma-induced inflammation (A) and in TNFα-stimulated (B) cremaster muscle venules of saline treated WT (control) and <i>RAGE^−/−</i> mice. Effect of PC treatment (100 U/kg, 3 h) on leukocyte adhesion in WT and <i>RAGE^−/−</i> mice represented as relative decrease [%] of leukocyte adhesion during trauma (C) and TNFα (D) induced inflammation. Effect of aPC treatment (24 µg/kg/h, 3 h) on leukocyte adhesion in WT and <i>RAGE^−/−</i> mice represented as relative decrease [%] of leukocyte adhesion during trauma (E) and TNFα (F) induced inflammation. All values are presented as mean+SEM from three or more mice per group. Significant differences (<i>P</i><0.05) to WT mice are indicated by the asterisks.