Effect of EEAC on P-glycoprotein ATPase activity.

<p>(<i>a</i>) Incubation with EEAC (0.01–200 µg/ml) stimulated the P-gp ATPase activity. Data were analyzed in terms of RLUs. (<i>b</i>) Verapamil (25–400 µM) showed its capacity to stimulate P-gp ATPase activity. (<i>c</i>) EEAC (1–100 µg/ml) was tested for its capacity to inhibit 200 µM verapamil-stimulated P-gp ATPase activity. Above results indicated that EEAC stimulated the P-gp ATPase activity and inhibited 200 µM verapamil-stimulated P-gp ATPase activity at concentration 5 µg/ml.