The effects of 5-day genistein treatment on spatial learning memory evaluated with Morris water maze task.

<p>The swimming distance (A and B) and escape latency (C and D) of the experimental animals to find the platform during the 3 consecutive days of Morris water maze task was plotted. The average swimming speed of each animal was shown in E. Young adult: young adult female rats; OHE-2W: OHE and survived for 2 weeks and vehicle-treated; OHE-2W+GS: OHE-2W females treated with genistein; OHE-8W: OHE for 8 weeks and vehicle-treated; OHE-8W+GS: OHE-8W females treated with genistein; late middle age: late middle age females without vehicle treatment; late middle age+V: late middle age females treated with vehicle; late middle age+GS: late middle age females treated with genistein; late middle age+E2: late middle age females treated with estradiol. *, p<0.05 between the marked and young adult, two-way ANOVA followed by S-N-K test. Vertical bar represents standard error of the mean.