Treatment With B20.4.1.1 or K(1-3) has no Effect on VEGF Expression During EAE.

<p>A,B. Bar charts show per mouse data on VEGF expression, using the % area of positive staining in the dorsal columns. Control mice were disease-free. EAE alone is compared to mice treated during EAE with B20-4.1.1 (A) or K(1-3) (B). Day 21 data is further subdivided into high and low expression (n = 6 mice in EAE alone, n = 5 at day 21, high expression group n = 3/5, low n = 2/5; n = 9 mice for B20-4.1.1 treated mice, n = 5/9 for high expression group, low n = 4/9; n = 10 mice for K(1-3) treated mice, n = 6/10 for high expression group, low n = 4/10; data is mean ± SEM, significance relative to untreated controls, *–***, P<0.05–0.001). C–E. Representative images of dorsal column expression of VEGF for untreated controls (C), high expression B20.4.1.1 treated EAE day 21 (D) and low expression K(1-3) treated EAE day 21 (E). Scale bar = 100 µm.