Combinations of NRTIs are highly effective against HIV-1 cell-to-cell transmission.

<p>(<b>A, B</b>) An experiment as in <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1003982#ppat-1003982-g002" target="_blank">Fig. 2</a> was performed for the combinations (black lines) of (<b>A</b>) AZT and TFV and (<b>B</b>) 3TC and ABC and compared to each single inhibitor treatment (red lines, left and right panel). The X-axis represents the drug concentration of the drug within the combination that is being compared to the single drug treatment (in red). See Supplementary <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1003982#ppat.1003982.s008" target="_blank">Fig. S8A</a> for additional inhibitor combinations. (<b>C</b>) The change in IC₉₀ for co-culture over cell-free infection for the single inhibitors was compared to all the inhibitor combinations tested. (<b>D</b>) The change in average IIP at IC_Max for co-culture over cell-free infection for the single inhibitors was compared to all the inhibitor combinations tested. See Supplementary <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1003982#ppat.1003982.s008" target="_blank">Fig. S8B</a> for complete set of average IIP data. (<b>E</b>) Cell-free and co-culture infection of primary cells with HIV-1_NL4-3 carrying the M184V mutation of reverse transcriptase (black line) compared to wild-type HIV-1_NL4-3 (red line) in the presence of increasing concentrations of AZT. Error bars represent the standard deviation from the combination of at least two individual experiments each done in triplicate.