Summary of the proteome changes accompanying purine starvation.

<p>The proteomes of cells incubated in either purine-replete or in purine-deplete media were compared at 6, 12, 24, and 48 h post purine supplement removal. Large circles and the numbers within represent the total number of proteins that could be assigned between purine-replete and purine-deplete cells at each time point. Small circles and numbers in parentheses refer to the number of proteins significantly changed (p-value <0.05) at each time point between purine-replete and purine-deplete cells. Light red and light green fractions and corresponding numbers indicate proteins upregulated or downregulated, respectively, by less than 2-fold, dark red and dark green portions and corresponding numbers indicate proteins upregulated or downregulated, respectively, by 2-fold or more.