CEP-1 mediates the longevity and development of two mitochondrial mutants in <i>C. elegans</i>.

<p>(A) <i>cep-1</i> mutation partially suppresses <i>isp-1</i> mutant longevity as the <i>cep-1;isp-1</i> double mutant lifespan is shorter than that of the <i>isp-1</i> single mutant. (B) <i>cep-1</i> mutation restores the <i>mev-1</i> mutant lifespan as the lifespans of two <i>cep-1;mev-1</i> isolates (L1, L32) are similar to that of wt. (C) The percentage of worms at each developmental stage was quantified for wt, <i>cep-1, isp-1, cep-1;isp-1, mev-1</i>, and <i>cep-1;mev-1</i> mutant worms after 60 hr of growth from the embryonic stage at 20°C. (D) The average number of progeny production for each line was calculated from 5 to 10 worms. The <i>isp-1</i> and <i>mev-1</i> mutants produce significantly less progeny than wt. The <i>cep-1;isp-1</i> and <i>cep-1;mev-1</i> double mutants display significantly lower brood sizes than their respective single mutant controls (*<i>p</i><0.05, **<i>p</i><0.0005). The error bars represent standard errors. Statistical analysis was performed using a two-tailed t-test.