<p>(A, B) RNAi-mediated knockdown of <i>ftn-1</i> attenuates the long life of the <i>nuo-6</i> mutant but does not impact the lifespan of the short-lived <i>gas-1</i> mutant. (C) qRT-PCR results of <i>ftn-1</i> expression levels in various ETC mutants. The two-tailed student t-tests were performed to determine significant difference in <i>ftn-1</i> expression levels with and without CEP-1 in each ETC mutant background.</p
<p>Decreasing <i>pqm-1</i> expression by RNAi decreased the lifespan of <i>clk-1</i> (<b>A</b>), <i>...
<p>Decreasing the expression of <i>math-33</i> by RNAi reduced the lifespan of the long-lived mitoch...
<p>(A) Effect of treatment of <i>eri-3(mg408); eak-4(mg348)</i> mutants with RNAi clones for <i>daf-...
<p>A) The lifespans of wild-type animals and <i>hlh-29</i> mutants are similarly affected by 24 mM F...
<p>(A–K) These genes are similarly regulated by CEP-1 between <i>isp-1</i> and <i>mev-1</i> mutants....
<p>(A) <i>Pftn-1::gfp</i> expression in wt, <i>cep-1, isp-1, cep-1;isp-1, mev-1</i>, and <i>cep-1;me...
<p><b>A</b> Expression profiles of genes involved in various metabolic pathways: TCA cycle with mala...
<p>A) <i>hlh-29</i> mutants show increased resistance to 10 mM t-BOOH when compared to wild-type ani...
<p>A) RT-qPCR measurements of <i>ftn-1</i> mRNA under normal iron conditions in indicated genetic ba...
<p>(A) <i>cep-1</i> mutation fully suppresses the long lifespan of the <i>nuo-6</i> mutant. (B) <i>c...
<p><b>A</b> Relative <i>sdhb-1</i> transcript levels in wild type (N2), <i>gas-1(fc21) and nuo-6(qm2...
<div><p><i>Caenorhabditis elegans</i> CEP-1 and its mammalian homolog p53 are critical for respondin...
<p>(A) Treatment of the <i>rpn-10</i> mutant, but not wild-type animals with <i>elt-2</i> RNAi resul...
<p>(A) RNA blot assays of small RNAs in wild type and <i>henn-1</i> mutant embryos and adults. For e...
Caenorhabditis elegans CEP-1 and its mammalian homolog p53 are critical for responding to diverse st...
<p>Decreasing <i>pqm-1</i> expression by RNAi decreased the lifespan of <i>clk-1</i> (<b>A</b>), <i>...
<p>Decreasing the expression of <i>math-33</i> by RNAi reduced the lifespan of the long-lived mitoch...
<p>(A) Effect of treatment of <i>eri-3(mg408); eak-4(mg348)</i> mutants with RNAi clones for <i>daf-...
<p>A) The lifespans of wild-type animals and <i>hlh-29</i> mutants are similarly affected by 24 mM F...
<p>(A–K) These genes are similarly regulated by CEP-1 between <i>isp-1</i> and <i>mev-1</i> mutants....
<p>(A) <i>Pftn-1::gfp</i> expression in wt, <i>cep-1, isp-1, cep-1;isp-1, mev-1</i>, and <i>cep-1;me...
<p><b>A</b> Expression profiles of genes involved in various metabolic pathways: TCA cycle with mala...
<p>A) <i>hlh-29</i> mutants show increased resistance to 10 mM t-BOOH when compared to wild-type ani...
<p>A) RT-qPCR measurements of <i>ftn-1</i> mRNA under normal iron conditions in indicated genetic ba...
<p>(A) <i>cep-1</i> mutation fully suppresses the long lifespan of the <i>nuo-6</i> mutant. (B) <i>c...
<p><b>A</b> Relative <i>sdhb-1</i> transcript levels in wild type (N2), <i>gas-1(fc21) and nuo-6(qm2...
<div><p><i>Caenorhabditis elegans</i> CEP-1 and its mammalian homolog p53 are critical for respondin...
<p>(A) Treatment of the <i>rpn-10</i> mutant, but not wild-type animals with <i>elt-2</i> RNAi resul...
<p>(A) RNA blot assays of small RNAs in wild type and <i>henn-1</i> mutant embryos and adults. For e...
Caenorhabditis elegans CEP-1 and its mammalian homolog p53 are critical for responding to diverse st...
<p>Decreasing <i>pqm-1</i> expression by RNAi decreased the lifespan of <i>clk-1</i> (<b>A</b>), <i>...
<p>Decreasing the expression of <i>math-33</i> by RNAi reduced the lifespan of the long-lived mitoch...
<p>(A) Effect of treatment of <i>eri-3(mg408); eak-4(mg348)</i> mutants with RNAi clones for <i>daf-...