CEP-1 mediates the longevity and development of several mitochondrial mutants in <i>C. elegans</i>.

<p>(A) <i>cep-1</i> mutation fully suppresses the long lifespan of the <i>nuo-6</i> mutant. (B) <i>cep-1</i> mutation does not suppress <i>clk-1</i> mutant longevity as the lifespans of two <i>cep-1;clk-1</i> double mutant isolates (L4, L6) are similar to that of the <i>clk-1</i> single mutant. (C) <i>cep-1</i> mutation partially restores <i>gas-1</i> mutant lifespan as two isolates of <i>cep-1;gas-1</i> (L22, L34) live longer than the <i>gas-1</i> single mutant. (D) The percentage of worms at each developmental stage was quantified as described in <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1004097#pgen-1004097-g001" target="_blank">Fig. 1C</a>. <i>cep-1</i> deletion has little impact on <i>nuo-6</i> and <i>gas-1</i> mutant development.