Dose-dependent relationship between genotype GG, GX and XX of rs842999 and serum 25(OH)D concentrations.

<p>X-axis stands for genotype GG (GG), GX (GC or GA) and XX (CC, CA or AA) of rs842999. Y-axis stand for serum 25(OH)D (nmol/L). Errors bars stand for 95%-confidence interval and serum 25(OH)D concentrations are given as geometric means. Linear mixed models with family as a random factor, adjusted for age, sex, BMI, ski and sun holidays, solarium use at least once a week, dietary vitamin D intake, multivitamin and vitamin D supplement users was conducted to compare rs842999 genotypes with serum 25(OH)D concentrations. There was a dose-dependent relationship between serum 25(OH)D concentrations and carriers of none, one or two copies of the G-allele. Carriers of two copies of the G-allele, had higher serum 25(OH)D concentrations compared to carriers with only one G-allele or non-carriers in children, adults and all combined, respectively.