Overview of sequences found to be hypermutated.

<p>Every sequence found to be hypermutated in our data set has a column (51 of 77 human sequences, and 105 of 1097 monkey blood sequences and 8 of 152 monkey buccal sequences). The top plot represents hypermutation intensity, where the dot shows the Maximum A Posteori (MAP) value for the relative probability ratio and the lower limit of the line shows the 0.05 quantile. Sequences colored by species and sample type (whole blood (WB) or buccal swab (BS)). The call pattern is the context in which the strongest dinucleotide hypermutation signal was found (using IUPAC degenerate nucleotide notation). “Stops” signifies the presence of in frame stop codons.