Spontaneous postsynaptic currents in Purkinje cells.

<p><b>(A)</b> Representative traces of spontaneous EPSCs and IPSCs in control and <i>Cstb^−/−</i> Purkinje cells. EPSCs are seen as inward currents (downward deflections) and IPSCs are seen as outward currents (upward deflections). Insets show single IPSCs and EPSCs taken from the time points indicated by asterisks. An arrow indicates a synchronous burst of IPSCs seen in control but not in <i>Cstb^−/−</i> Purkinje cells. <b>(B)</b> The occurrence of IPSCs and synchronous burst of IPSCs on control and <i>Cstb^−/−</i> Purkinje cells. Individual cells measured are shown as spheres. <b>(C)</b> The frequency of EPSCs was significantly higher in <i>Cstb^−/−</i> cells compared to controls (p = 0.034). The data are expressed as mean frequency (Hz) ± SE. *, p<0.05; **, p<0.01.