Baicalein suppresses the expression and activity of MMP-2 and MMP-9 and promotes the expression of TIMP-1 and TIMP-2 in U87MG cells.

<p>(A) The effects of baicalein on the expression of MMP-2 and MMP-9 were assessed by RT-PCR. (B) The protein levels of MMP-2 and MMP-9 were analyzed in U87MG cells treated with baicalein (0, 10, 20 and 40 µM) for 24 h using Western blotting. (C) Quantification of (B). (D) Effects of baicalein on the activities of MMP-2 and MMP-9. (E) Quantification of (D). (F) The protein levels of TIMP-1 and TIMP-2 were analyzed in U87MG cells treated with baicalein (0, 10, 20 and 40 µM) for 24 h using Western blotting. (G) Quantification of (F). Values represent the means ± SD of three independent experiments performed in triplicate. *<i>p</i><0.05 and **<i>p</i><0.01 compared with the control group.