A simple model of paired pulse depression accurately modeled synaptic plasticity as seen in vitro.

<p><b><i>A.</i></b> A recorded autaptic burst at 50(blue) showing paired pulse depression (data taken from <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0089995#pone.0089995-Connelly1" target="_blank">[15]</a>). The computation model (red) is a close fit. <b><i>B.</i></b> Summary statistics showing paired pulse depression at autaptic connections in response to trains at several different stimulus intensities during in vitro recording (filled symbols) and during a computational model (open symbols). <b><i>C.</i></b> An <i>in vitro</i> recording of the recovery from synaptic depression (blue) fits closely with the recovery as generated by the model (red). <b><i>D.</i></b> Measurements of the computational model perfectly recreate the recovery from synaptic depression. Results are reported as the amplitude of the second synaptic event (P2) as divided by the amplitude of the first synaptic event (P1).