<p>(A) Ba/F3 ponatinib-resistant cells were treated with various concentrations of imatinib, nilotinib, or dasatinib, and cellular growth was analyzed. These experiments were performed in triplicate. (B) Ba/F3 ponatinib-resistant cells were treated with imatinib, nilotinib, or dasatinib for 24 h. Whole cell lysates were analyzed by immunoblotting with phospho-specific Abl and Crk-L Abs. β-tubulin was used as the loading control.</p
<p>Two cell lines, HEK293-pcDNA3.1 and HEK-MRP7-2, are represented as HEK293 and MRP7, respectively....
<p>Cells were maintained in supplemented medium for 12 h, and then incubated with nilotinib (0∼100 µ...
Item does not contain fulltextThe discovery of oncogenes and tumor suppressors as a driver of cancer...
<p>(A) K562 cells were cultured at a concentration of 8×10<sup>4</sup>/mL in the presence of varying...
International audienceThe advent of tyrosine kinase inhibitor (TKI) therapy has considerably improve...
The use of tyrosine kinase inhibitors (TKIs), which target Bcr-Abl, has become the first-line trea...
<p>(A) Quantification of response to imatinib by clonogenic survival assay under different media con...
Targeting the tyrosine kinase activity of BCR-ABL is the gold standard strategy in Chronic Myeloid L...
<p>(A) Cells were cultured at a concentration of 8×10<sup>4</sup>/mL in the presence or absence of p...
Resistance to imatinib (Gleevec®) in cancer cells is frequently because of acquired point mutations ...
<div><p>Resistance to imatinib (Gleevec®) in cancer cells is frequently because of acquired point mu...
<p>Baf-3 cells expressing either wild type (WT) or T315I mutant BCR-ABL (T315I) were treated with th...
<p>(A) Sequence and position of the BIRC6 phosphopeptide. (B) Short-term ponatinib treatment of MYL-...
Chronic myeloid leukemia (CML) is a type of hematological malignancy that is characterized by the ge...
<p><b>A</b>. Ba/F3 cells stably transfected with T315I-BCR-ABL were treated with ponatinib (10 nM) o...
<p>Two cell lines, HEK293-pcDNA3.1 and HEK-MRP7-2, are represented as HEK293 and MRP7, respectively....
<p>Cells were maintained in supplemented medium for 12 h, and then incubated with nilotinib (0∼100 µ...
Item does not contain fulltextThe discovery of oncogenes and tumor suppressors as a driver of cancer...
<p>(A) K562 cells were cultured at a concentration of 8×10<sup>4</sup>/mL in the presence of varying...
International audienceThe advent of tyrosine kinase inhibitor (TKI) therapy has considerably improve...
The use of tyrosine kinase inhibitors (TKIs), which target Bcr-Abl, has become the first-line trea...
<p>(A) Quantification of response to imatinib by clonogenic survival assay under different media con...
Targeting the tyrosine kinase activity of BCR-ABL is the gold standard strategy in Chronic Myeloid L...
<p>(A) Cells were cultured at a concentration of 8×10<sup>4</sup>/mL in the presence or absence of p...
Resistance to imatinib (Gleevec®) in cancer cells is frequently because of acquired point mutations ...
<div><p>Resistance to imatinib (Gleevec®) in cancer cells is frequently because of acquired point mu...
<p>Baf-3 cells expressing either wild type (WT) or T315I mutant BCR-ABL (T315I) were treated with th...
<p>(A) Sequence and position of the BIRC6 phosphopeptide. (B) Short-term ponatinib treatment of MYL-...
Chronic myeloid leukemia (CML) is a type of hematological malignancy that is characterized by the ge...
<p><b>A</b>. Ba/F3 cells stably transfected with T315I-BCR-ABL were treated with ponatinib (10 nM) o...
<p>Two cell lines, HEK293-pcDNA3.1 and HEK-MRP7-2, are represented as HEK293 and MRP7, respectively....
<p>Cells were maintained in supplemented medium for 12 h, and then incubated with nilotinib (0∼100 µ...
Item does not contain fulltextThe discovery of oncogenes and tumor suppressors as a driver of cancer...