LPS induced cytokine production in islets.

<p>Islets from db/+, db/db, and MIN6 cells left untreated or treated with the indicated LPS concentrations for 24 h and media. LPS induced dose-response of IL-6 (A). Release of IL-6 (B), MCP-1 (C), KC (D) and RANTES (E) from db/+ and db/db islets treated with 1 µg/ml LPS or media alone. Data shows mean from 20 mice run in triplicate. All data are shown as mean ± S.E.M. Statistical analysis is derived by student’s T-test*p<0.05; p<0.01; p<0.001.